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can lead to overdose and death (see warnings ). Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. If you have been taking tylenol with Codeine tablets regularly, do not stop taking tylenol with Codeine tablets without talking to your healthcare provider. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. Monitor patients closely for respiratory depression, especially within the first 2472 hours of initiating therapy and following dosage increases with tylenol with Codeine tablets and adjust the dosage accordingly (see warnings ).
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In contrast, there was no evidence of carcinogenic activity in male rats that received up.7 times or mice at up.21.4 times the mhdd, based on a body surface area comparison. Similarly there was no evidence of carcinogenicity activity in male and female mice at dietary doses up to 400 mg/kg/day of codeine sulfate (approximately 5 times the maximum recommended daily dose of 360 mg/day for adults on a mg/m2 basis) for two years. Monitor patients for respiratory depression and sedation at frequent intervals. If patients have been receiving treatment with tylenol with Codeine tablets for more than a few weeks and cessation of therapy is indicated, counsel them on the importance of safely tapering the dose and that abruptly discontinuing the medication could precipitate withdrawal symptoms. If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower initial dose of the opioid analgesic, and titrate based on clinical response. Breastfeeding is not recommended during treatment with tylenol with Codeine tablets. 3/1 Persil ProClean Laundry Detergent, exp. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation.
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